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D-Neopterin
CAS No:   2009-64-5
Usage:  
Introduction

D-Neopterin

 

Molecular Formula:C9H11N5O4

 

CAS Number:2009-64-5

 

Formula Weight:253.2

 

Description:White or Yellow powder

 

Biochemical functions:Neopterinhas two isomers (D- and L-Neopterin). We sell only D-Neopterin. D-Neopterin is the natural form. The determination of neopterin concentrations is a sensitive method of monitoring the activity of the cellular immune system because of the close association of the stimulation of T-lymphocytes, the release of interferon and the synthesis of neopterin.

The levels of neopterin are higher in patients with certain infections ,with some tumours, with autoimmune diseases and in those rejecting transplants.

Dihydroneopterin triphosphate is part of the synthesis pathway of tetrahydrobioptrinm, an important cofactor in humans.

 

Solubility: Neopterin is practically insoluble in water. its solubility is about 0.005 g per 100 g of water (220C). Concentrated solutions  may be prepared using 0.05M NaOH. Ultrasonication may be used to improve dissolution.

 

Analytical methods:

        HPLC conditions:  Column: Waters Spherisorb S5 ODS1

                          Eluant: 10mM Na2HPO4 PH 6

                          Flow rate: 1ml/min

                          Wavelength: 254nm

                          Sample: 1mg/ml 0.05N NaOH

 

        TLC conditions:    Stationary phase: cellulose

                          Eluant: water

 

Specifications: Purity: HPLC   >99.0%

                   TLC    one blue fluorescent spot at 366nm

 

Stability: Neopterin is light sensitive. Neopterin contains half a mole of water.

 

Storage: Keep the powder dry in tightly closed bottle coloured , at –200C. Neopterin can be transported without the use of dry ice. In tightly closed bottle, wrapped in aluminium foil, it is stable at ambient temperature for several months.

 

Uses:Neopterin is an important standard for analytical work .it can be used in the screening of blood donors for various diseases.

 

Safety information: Neopterin is known to be safe and there are no special precautions required in handling this product.

 

Remarks: The information in this publication is based on our current knowledge and experience. It does not relieve users or processors from carrying out their own precautions and tests.

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